Search results for "Ciências Médicas::Medicina Básica"

showing 8 items of 8 documents

Effects of the LPA1 Receptor Deficiency and Stress on the Hippocampal LPA Species in Mice

2019

Lysophosphatidic acid (LPA) is an important bioactive lipid species that functions in intracellular signaling through six characterized G protein-coupled receptors (LPA1-6). Among these receptors, LPA1 is a strong candidate to mediate the central effects of LPA on emotion and may be involved in promoting normal emotional behaviors. Alterations in this receptor may induce vulnerability to stress and predispose an individual to a psychopathological disease. In fact, mice lacking the LPA1 receptor exhibit emotional dysregulation and cognitive alterations in hippocampus-dependent tasks. Moreover, the loss of this receptor results in a phenotype of low resilience with dysfunctional coping in res…

0301 basic medicineElevated plus mazemedicine.medical_specialtyMALDI-TOFF mass spectrometry:Medicina Básica [Ciências Médicas]BiologyHippocampal formationemotionslcsh:RC321-57103 medical and health scienceschemistry.chemical_compoundstressCellular and Molecular Neuroscience0302 clinical medicineInternal medicineLysophosphatidic acidmedicineReceptorlcsh:Neurosciences. Biological psychiatry. NeuropsychiatryMolecular BiologyScience & TechnologyEmotional dysregulationmedicine.diseasePhenotypeLPA species030104 developmental biologyEndocrinologychemistryMood disordersCiências Médicas::Medicina Básicalipids (amino acids peptides and proteins)LPA receptor 1LPA1 receptorbiological phenomena cell phenomena and immunity030217 neurology & neurosurgeryIntracellularLPA(1) receptorFrontiers in Molecular Neuroscience
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Allergic Rhinitis and its Impact on Asthma (ARIA) Phase 4 (2018): Change management in allergic rhinitis and asthma multimorbidity using mobile techn…

2019

Allergic Rhinitis and its Impact on Asthma (ARIA) has evolved from a guideline by using the best approach to integrated care pathways using mobile technology in patients with allergic rhinitis (AR) and asthma multimorbidity. The proposed next phase of ARIA is change management, with the aim of providing an active and healthy life to patients with rhinitis and to those with asthma multimorbidity across the lifecycle irrespective of their sex or socioeconomic status to reduce health and social inequities incurred by the disease. ARIA has followed the 8-step model of Kotter to assess and implement the effect of rhinitis on asthma multimorbidity and to propose multimorbid guidelines. A second c…

AllergyAllergy:Medicina Básica [Ciências Médicas]asthma -- guidelineAllergic asthmaDECISION-MAKINGAllergic Rhinitis and Its Impact on AsthmaGUIDELINESMedical and Health SciencesMedical Records0302 clinical medicineHealth careImmunology and Allergy030212 general & internal medicineAllergic Rhinitis and Its Impact on Asthma; asthma; Change management; rhinitis; Immunology and Allergy; ImmunologyMASK-RHINITISComputingMilieux_MISCELLANEOUSRinitismobilne aplikacijeupravljanje spremembMedical recordGLOBAL STRATEGYWORK PRODUCTIVITYTelemedicinemobile applications3. Good healthAsma alérgicarhiniti1107 ImmunologyCiências Médicas::Medicina Básicaklinične potiallergic -- guidelineLife Sciences & BiomedicineHumanPATIENT PARTICIPATIONAllergic RhinitisTelemedicinemedicine.medical_specialtyanimal structuresmultimorbidityEUROPEAN INNOVATION PARTNERSHIPImmunologyChange Management[object Object]Settore MED/10 - Malattie Dell'Apparato RespiratorioAsthma/diagnosisCHRONIC DISEASESMACVIA-ARIA03 medical and health sciencesrhinitismedicinemultimorbidnostQUALITYHumanscritical pathwaysastma -- smernicaPatient participationAsmaudc:616.2AsthmaScience & TechnologyARIAbusiness.industryAllergic Rhinitis and Its Impact on Asthma; asthma; Change management; rhinitis; Change Management; Humans; Medical Records; Asthma; Multimorbidity; Rhinitis Allergic; TelemedicineSettore MED/09 - MEDICINA INTERNAchange managementMultimorbidityMobile Airways Sentinel Network (MASK) Study GroupGuidelineasthmata3121medicine.diseaseRinite alérgicaRhinitis AllergicRhinitis Allergic/diagnosisAsthmaIntegrated carealergijski rinitis -- smernicaAllergic Rhinitis and Its Impact on Asthma asthma Change management rhinitis Immunology and Allergy Immunology030228 respiratory systemFamily medicine3121 General medicine internal medicine and other clinical medicineMedical RecordClinical Medicinebusiness[SDV.MHEP]Life Sciences [q-bio]/Human health and pathologyImpact on AsthmaJournal of Allergy and Clinical Immunology
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Universality of the Triangular Theory of Love: Adaptation and Psychometric Properties of the Triangular Love Scale in 25 Countries

2021

The Triangular Theory of Love (measured with Sternberg’s Triangular Love Scale – STLS) is a prominent theoretical concept in empirical research on love. To expand the culturally homogeneous body of previous psychometric research regarding the STLS, we conducted a large-scale cross-cultural study with the use of this scale. In total, we examined more than 11,000 respondents, but as a result of applied exclusion criteria, the final analyses were based on a sample of 7332 participants from 25 countries (from all inhabited continents). We tested configural invariance, metric invariance, and scalar invariance, all of which confirmed the cultural universality of the theoretical construct of love …

Cross-Cultural Comparison:Ciências Sociais::Sociologia [Domínio/Área Científica]Sociology and Political ScienceScale (ratio)Psychometrics:Humanidades::Outras Humanidades [Domínio/Área Científica]Evolutionary psychology:Ciências Sociais::Outras Ciências Sociais [Domínio/Área Científica]Empirical Research:Ciências Sociais::Psicologia [Domínio/Área Científica]Romantic loveCommitment deviceGender StudiesQuality of alternativesEmpirical researchHistory and Philosophy of ScienceThe Triangular Theory of Love cross-culturalHumansTriangular theory of loveStatistical physicsCross-cultural studyAdaptation (computer science)General PsychologyMathematicsTriangular Love Scale:Ciências Médicas::Medicina Básica [Domínio/Área Científica]05 social sciencesSDG 10 - Reduced InequalitiesLoveSettore M-PSI/05 - PSICOLOGIA SOCIALEUniversality (dynamical systems)Close relationshipsPsychometric PropertiesTriangular Love Scale; Psychometric Properties; Cross-cultural study050903 gender studiesHomogeneous/dk/atira/pure/sustainabledevelopmentgoals/reduced_inequalities0509 other social sciencesJournal of Sex Research
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Mild cognitive decline. A position statement of the Cognitive Decline Group of the European Innovation Partnership for Active and Healthy Ageing (EIP…

2016

Introduction: Mild cognitive impairment (MCI) is a term used to describe a level of decline in cognition which is seen as an intermediate stage between normal ageing and dementia, and which many consider to be a prodromal stage of neurodegeneration that may become dementia. That is, it is perceived as a high risk level of cognitive change. The increasing burden of dementia in our society, but also our increasing understanding of its risk factors and potential interventions, require diligent management of MCI in order to find strategies that produce effective prevention of dementia. Aim: To update knowledge regarding mild cognitive impairment, and to bring together and appraise evidence abou…

GerontologyAgingConsensusRisk factors in diseases:Medicina Básica [Ciências Médicas]Psychological interventionPosition statementPrevention of dementiaGeneral Biochemistry Genetics and Molecular Biology03 medical and health sciences0302 clinical medicineCognitionRisk FactorsEnvellimentTerminology as TopicIntervention (counseling)Mild cognitive declinemental disordersPrevalenceHumansMedicineDementiaPsychologyCognitive DysfunctionProspective Studies030212 general & internal medicineCognitive declineDemènciaScience & TechnologyCognitive frailtybusiness.industryFactors de risc en les malaltiesProdromal StageObstetrics and GynecologyCognitionmedicine.diseasePsicologiaCiências Médicas::Medicina BásicaCognicióDisease ProgressionTrastorns de la memòria en la vellesaDementiabusiness030217 neurology & neurosurgeryIndependent living
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Physiological parameters for Prognosis in Abdominal Sepsis (PIPAS) Study: a WSES observational study

2019

Timing and adequacy of peritoneal source control are the most important pillars in the management of patients with acute peritonitis. Therefore, early prognostic evaluation of acute peritonitis is paramount to assess the severity and establish a prompt and appropriate treatment. The objectives of this study were to identify clinical and laboratory predictors for in-hospital mortality in patients with acute peritonitis and to develop a warning score system, based on easily recognizable and assessable variables, globally accepted. Background Timing and adequacy of peritoneal source control are the most important pillars in the management of patients with acute peritonitis. Therefore, early pr…

Male:Medicina Básica [Ciências Médicas]030230 surgeryLogistic regression0302 clinical medicineInjury Severity ScoreInterquartile rangeRisk FactorsAntibioticsAbdomenDiagnosisAcute peritonitis; Early warning score; Emergency surgery; Source control; Abdomen; Adult; Aged; Chi-Square Distribution; Female; Hospital Mortality; Humans; Injury Severity Score; Logistic Models; Male; Middle Aged; Risk Factors; Sepsis; PrognosisHospital MortalityMortality rateAcute peritonitilcsh:Medical emergencies. Critical care. Intensive care. First aidaarly warning scoreAcute peritonitisMiddle AgedEarly warning scorePrognosisacute peritonitis; aarly warning score; emergency surgery; source control; abdomen; adult; aged; chi-square distribution; female; hospital mortality; humans; injury severity score; logistic models; male; middle aged; risk factors; sepsis; prognosis3. Good healthManagementCiências Médicas::Medicina BásicaEmergency MedicineEmergency surgeryInjury Severity ScoreFemaleResearch ArticleHumanAdultmedicine.medical_specialtyLogistic ModelSepsilcsh:SurgeryNO03 medical and health sciencesSource controlInternal medicineSepsismedicineHumansAgedAcute appendicitisScience & TechnologyChi-Square Distributionbusiness.industryAcute peritonitis; Early warning score; Emergency surgery; Source controlRisk FactorAcute appendicitis; Antibiotics; Diagnosis; Management; SurgeryEarly warning scorelcsh:RD1-811lcsh:RC86-88.93126 Surgery anesthesiology intensive care radiologymedicine.diseaseAcute peritonitis ; Early warning score ; Emergency surgery ; Source controlLogistic ModelsObservational studySurgerybusinessChi-squared distributionKidney disease
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Prospective Observational Study on acute Appendicitis Worldwide (POSAW)

2018

Acute appendicitis (AA) is the most common surgical disease, and appendectomy is the treatment of choice in the majority of cases. A correct diagnosis is key for decreasing the negative appendectomy rate. The management can become difficult in case of complicated appendicitis. The aim of this study is to describe the worldwide clinical and diagnostic work-up and management of AA in surgical departments.

Male:Medicina Básica [Ciências Médicas]Computed tomography030230 surgery0302 clinical medicineAntibioticsDiagnosisAppendicitiProspective StudiesLaparoscopyProspective cohort studyTomographymedicine.diagnostic_testAcute appendicitis; Antibiotics; Diagnosis; Management; Surgery; Surgery; Emergency MedicineAcute appendicitis; Antibiotics; Diagnosis; Management; Surgery; Acute Disease; Adult; Appendectomy; Appendicitis; Chi-Square Distribution; Female; Hospitalization; Humans; Laparoscopy; Length of Stay; Logistic Models; Male; Prospective Studies; Tomography X-Ray Computed; Treatment OutcomeMortality ratelcsh:Medical emergencies. Critical care. Intensive care. First aidApendicite3. Good healthX-Ray ComputedManagementHospitalizationTreatment Outcome030220 oncology & carcinogenesisCiências Médicas::Medicina BásicaAcute appendicitisAcute DiseaseEmergency MedicineFemaleAcute appendicitis; Antibiotics; Diagnosis; Management; Surgery; Acute Disease; Adult; Appendectomy; Appendicitis; Chi-Square Distribution; Female; Hospitalization; Humans; Laparoscopy; Length of Stay; Logistic Models; Male; Prospective Studies; Tomography X-Ray Computed; Treatment Outcome; Surgery; Emergency MedicineDiagnosiHumanResearch ArticleAdultmedicine.medical_specialtyLogistic Modellcsh:SurgeryNO03 medical and health sciencesmedicineAppendectomyHumansAcute appendicitisChi-Square Distributionbusiness.industryGeneral surgeryAntibioticAcute appendicitis; Antibiotics; Diagnosis; Management; Surgerylcsh:RD1-811lcsh:RC86-88.9Length of Staymedicine.diseaseAppendicitisAppendicitisProspective StudieLogistic ModelsObservational studyLaparoscopySurgeryAcute appendicitibusinessTomography X-Ray ComputedChi-squared distributionWorld Journal of Emergency Surgery
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High-Grade T1 on Re-Transurethral Resection after Initial High-Grade T1 Confers Worse Oncological Outcomes: Results of a Multi-Institutional Study

2018

The aim of this multicenter study was to investigate the prognostic impact of residual T1 high-grade (HG)/G3 tumors at re-transurethral resection (TUR of bladder tumor) in a large multi-institutional cohort of patients with primary T1 HG/G3 bladder cancer (BC).

MaleTime Factorsmedicine.medical_treatment:Medicina Básica [Ciências Médicas]Treatment outcomeBladder cancer; High risk; High-grade; Second look resection; Transurethral resection of bladder tumor; Aged; Aged 80 and over; Carcinoma Transitional Cell; Cystectomy; Disease Progression; Disease-Free Survival; Female; Follow-Up Studies; Humans; Male; Middle Aged; Neoplasm Recurrence Local; Prognosis; Progression-Free Survival; Recurrence; Regression Analysis; Time Factors; Treatment Outcome; Urinary Bladder Neoplasms; Urologic Surgical Procedures030232 urology & nephrologySettore MED/24 - Urologia0302 clinical medicineRecurrenceHigh-grade80 and overAged 80 and overTransurethral resection of bladder tumorCARCINOMA TRANSITIONAL CELLHigh riskBladder cancerFollow up studiesMiddle AgedPrognosisProgression-Free Survival3. Good healthScholarshipTreatment OutcomeLocal030220 oncology & carcinogenesisCiências Médicas::Medicina BásicaUrinary Bladder NeoplasmDisease ProgressionRegression AnalysisUrologic Surgical ProceduresFemaleSecond look resectionHumanmedicine.medical_specialtyTime FactorPrognosiUrologyBladder cancer; High risk; High-grade; Second look resection; Transurethral resection of bladder tumorCystectomyRegression AnalysiDisease-Free SurvivalResectionFollow-Up StudieCystectomy03 medical and health sciencesbladder cancer; high risk; high-grade; second look resection; transurethral resection of bladder tumor; aged; aged 80 and over; carcinoma transitional cell; cystectomy; disease progression; disease-free survival; female; follow-up studies; humans; malemedicineHumansProgression-free survivalAgedCarcinoma Transitional CellScience & Technologybusiness.industryGeneral surgeryDisease progressionCarcinomaNeoplasm RecurrenceUrinary Bladder NeoplasmsUrologic Surgical ProcedureTransitional CellTransurethral resection of bladder tumor.Neoplasm Recurrence LocalbusinessFollow-Up Studies
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Systemic Inflammatory Markers and Oncologic Outcomes in Patients with High-risk Non-muscle-invasive Urothelial Bladder Cancer

2018

Background: Serum levels of neutrophils, platelets, and lymphocytes have been recognized as factors related to poor prognosis for many solid tumors, including bladder cancer (BC). Objective: To evaluate the prognostic role of the combination of the neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and lymphocyte/monocyte ratio (LMR) in patients with high-risk non–muscle-invasive urothelial BC (NIMBC). Design, setting, and participants: A total of 1151 NMIBC patients who underwent first transurethral resection of the bladder tumor (TURBT) at 13 academic institutions between January 1, 2002 and December 31, 2012 were included in this analysis. The median follow-up was 48 mo.…

OncologyMaleBladder cancer; Lymphocyte/monocyte ratio; Neutrophil/lymphocyte ratio; Platelet/lymphocyte ratio; Prognosis; Aged; Biomarkers Tumor; Blood Platelets; Carcinoma Transitional Cell; Cystectomy; Disease Progression; Female; Follow-Up Studies; Humans; Inflammation; Lymphocyte Count; Lymphocytes; Male; Monocytes; Neutrophils; Prognosis; Risk Factors; Urinary Bladder NeoplasmsNeutrophilsmedicine.medical_treatmentLymphocyte:Medicina Básica [Ciências Médicas]Prognosis.030232 urology & nephrologyMonocyteMonocytesSettore MED/24 - Urologia0302 clinical medicineRisk FactorsLymphocytesStage (cooking)Framingham Risk ScoreTumorNeutrophilBladder cancerPrognosis3. Good healthmedicine.anatomical_structureOncology030220 oncology & carcinogenesisNeutrophil/lymphocyte ratioCiências Médicas::Medicina BásicaDisease ProgressionLymphocyteFemalemedicine.symptomHumanBlood Plateletsmedicine.medical_specialtyPlatelet/lymphocyte ratioPrognosiUrologyInflammationCystectomyFollow-Up StudieCystectomy03 medical and health sciencesInternal medicinemedicineBiomarkers TumorHumansRadiology Nuclear Medicine and imagingLymphocyte CountAgedInflammationCarcinoma Transitional CellBladder cancerScience & Technologybusiness.industryProportional hazards modelRisk FactorCarcinomaLymphocyte/monocyte ratioImmunotherapymedicine.diseaseUrinary Bladder NeoplasmsBlood PlateletSurgeryTransitional CellbusinessBiomarkersFollow-Up Studies
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